Aim 1 – Outcome Measures

Bienvenu OJ, Williams JB, Yang A, Hopkins RO, Needham DM. Posttraumatic stress disorder in survivors of acute lung injury: evaluating the Impact of Event Scale-Revised. Chest. 2013. Jul; 144(1):24-31. PubMed

Chan KS, Aronson Friedman L, Dinglas VD, Hough CL, Morris PE, Mendez-Tellez PA, Jackson JC, Ely EW, Hopkins RO, Needham DM. Evaluating physical outcomes in ARDS survivors: validity, responsiveness & minimal important difference of 4-Meter Gait Speed Test. Critical Care Medicine. 2016; 44(5): 859-868. PubMed

Chan KS, Friedman LA, Bienvenu OJ, Dinglas VD, Cuthbertson BH, Porter R, Jones C, Hopkins RO, Needham DM. Distribution-based estimates of minimal important difference for Hospital Anxiety and Depression Scale and Impact of Event Scale-Revised in survivors of acute respiratory failure. General Hospital Psychiatry. 2016;42:32-35. Pubmed

Chan KS, Mourtzakis M, Friedman LA, Dinglas VD, Hough CL, Ely EW, Morris PE, Hopkins RO, Needham DM with the National Institutes of Health NHLBI ARDS Network. Upper arm anthropometrics versus DXA scan in survivors of acute respiratory distress syndrome. Eur J Clin Nutr. 2018. ePub ahead of print. PubMed.

Chan KS, Pfoh E, Denehy L, Elliott D, Holland AE, Dinglas VD, Needham DM. Construct validity and minimal important difference of 6-Minute Walk Distance in survivors of acute respiratory failure. Chest. 2015; 147(5):1316-1326. PubMed

Da Silva VZM, de Araújo Neto JA, Cipriano Jr. G, et al. Brazilian version of the Functional Status Score for the ICU: translation and cross-cultural adaptation. Revista Brasileira de Terapia Intensiva. 2017;29(1):34-38. PubMedFree Full Text Article (SciELO)

Dinglas VD, Chessare CM, Davis WE, Parker A, Friedman LA, Colantuoni E, Bingham CO, Turnbull AE, Needham DM. Perspectives of survivors, families, and researchers on key outcomes for research in acute respiratory failure. Thorax. 2017; In Press.

Eakin MN, Patel Y, Mendez-Tellez P, Dinglas VD, Needham DM, Turnbull AE. Patient outcomes after acute respiratory failure: A qualitative study of survivors’ experience using the PROMIS framework. American Journal of Critical Care. 2017;26:456-465. PubMed

Hashem MD, Nallagangula A, Nalamalapu S, Nunna K, Nausran U, Robinson KA, Dinglas VD, Needham DM, Eakin MN. Patient outcomes after critical illness: a systematic review of qualitative studies following hospital discharge. Critical Care. 2016 Oct 26;20(1):345. PubMed

Hodgson CL, Turnbull AE, Iwashyna TJ, Parker A, Davis W, Bingham CO, Watts NR, Finfer S, Needham DM. Core domains in evaluating patient outcomes after acute respiratory failure: international multidisciplinary clinician consultation. Physical Therapy Journal. 2016; 97 (2): 167-174. PubMed

Hopkins RO, Suchyta MR, Kamdar BB, Darowski E, Jackson JC, Needham DM. Instrumental activities of daily living after critical illness: a systematic review. Annals of the American Thoracic Society. 2017; 2017,14(8):1332-1343. PubMed

Huang M, Chan KS, Zanni JM, Parry SM, Neto SB, Neto JA, da Silva VZ, Kho ME, Needham DM. Functional status score for the intensive care unit (FSS-ICU): an international clinimetric analysis of validity, responsiveness, and minimal important difference. Critical Care Medicine. 2016 Dec;(44)12. PubMed

Jutte JE, Needham DM, Pfoh ER, Bienvenu OJ. Psychometric evaluation of the Hospital Anxiety and Depression Scale 3 months after acute lung injury. Journal of Critical Care. 2015; 30(4):793-798. PubMed Article (Journal of Critical Care)

Needham DM, Sepulveda KA, Dinglas VD, Chessare CM, Friedman LA, Bingham III CO, Turnbull AE. Core outcome measures for clinical research in acute respiratory failure survivors: an international modified Delphi consensus study. American Journal of Respiratory Critical Care Medicine. 2017;196:1122-1130. PubMed

Nikayin S, Rabiee A, Hashem MD, Huang M, Bienvenu OJ, Turnbull AE, Needham DM. Anxiety symptoms in survivors of critical illness: a systematic review and meta-analysis. General Hospital Psychiatry. 2016; 43:23-29. PubMed

Parry SM, Huang M, Needham D. Evaluating physical functioning in critical care: considerations for clinical practice and research. Critical Care. 2017, 21:249. Free full textPubMed

Pfoh ER, Chan KS, Dinglas VD, Cuthbertson BH, Elliott D, Porter R, Bienvenu OJ, Hopkins RO, Needham DM. The SF-36 offers a strong measure of mental health symptoms in acute respiratory failure survivors: a tri-national analysis. Annals of the American Thoracic Society.2016 Aug;13(8):1343-50. PubMed

Pfoh E, Chan KS, Dinglas VD, Girard TD, Jackson JC, Morris PE, Hough CL, Mendez-Tellez PA, Ely EW, Huang M, Needham DM, Hopkins RO and with the NIH NHLBI ARDS Network. Cognitive screening among acute respiratory failure survivors:  a cross-sectional evaluation of the Mini-Mental State Examination. Critical Care. 2015, 19:220 (5 May 2015). PubMed

Rabiee A, Nikayin S, Hashem MD, Huang M, Dinglas VD, Bienvenu OJ, Turnbull AE, Needham DM. Depressive symptoms after critical illness: a systematic review and meta-analysis. Critical Care Medicine. 2016; Sep;44(9):1744-53. doi: 10.1097/CCM.0000000000001811. PubMed

Robinson KA, Davis WE, Dinglas VD, Mendez-Tellez PA, Rabiee A, Sukrithan V, Yalamanchilli R, Turnbull AE, Needham DM. A systematic review finds limited data on measurement properties of instruments measuring outcomes in adult intensive care unit survivors. Journal of Clinical Epidemiology. 2017;82:37-46. PubMed

Turnbull AE, Rabiee A, Davis WE, Nasser MF, Venna VR, Lolitha R, Hopkins RO, Bienvenu OJ, Robinson KA, Needham DM. Outcome measurement in ICU survivorship research from 1970-2013: a scoping review of 425 publications. Critical Care Medicine. 2016 Jul;44(7):1267-77. PubMed

Turnbull AE, Sepulveda KA, Dinglas VD, Bingham CO, Needham, DM.  Core domains for clinical research in acute respiratory failure survivors: an international modified Delphi consensus study.  Critical Care Medicine. 2017 Jun;45(6):1001-1010. PubMed

Aim 2 – Cohort Retention

Abshire M, Dinglas VD, Cajita MIA, Eakin MN, Needham DM, Dennison Himmelfarb C. Participant retention practices in longitudinal clinical research studies with high retention rates. BMC Medical Research Methodology. 2017; 17:30. PubMed; Free Full Text Article (BioMed Central)

Dinglas VD,…, Needham DM. Long-term outcomes in ICU survivors: a systematic review of cohort retention. PROSPERO 2018 CRD42018087835 Available from:

Robinson KA, Dinglas VD, Sukrithan V, Yalamanchili R, Mendez-Tellez PA, Dennison-Himmelfarb C, Needham DM. Updated systematic review identifies substantial number of retention strategies:  Using more strategies retains more study participants. Journal of Clinical Epidemiology. 2015; 68(12):1481-7. PubMed

Turnbull AE, O’Conner CL, Lau B, Halpern SD, Needham DM. Allowing physicians to choose the value of compensation for participation in a web-based survey: randomized controlled trial. Journal of Medical Internet Research. 2015;17(7):e189. PubMed Article

Aim 3 – Statistical Methods

Colantuoni E, Scharfstein DO, Wang C, Hashem MD, Leroux A, Needham DM, Girard TD.  Statistical methods to compare functional outcomes in RCTs with high mortality.  British Medical Journal. 2018;360:j5748. Article

Colantuoni E, Dinglas VD, Ely EW, Hopkins RO, Needham DM. Statistical methods for evaluating delirium in the ICU. The Lancet Respiratory Medicine. 2016; 4(7): 534-536. Free Full Text Version

Wang C, Scharfstein DO, Colantuoni E, Girard TD, and Yan Y.  Inference in randomized trials with death and missingness. Biometrics. 2016;73(2):431-440. Article